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By T. Karmok. New York University. 2018.

Another difficulty is often the inability to understand body language order 5 mg emsam, tone of voice generic emsam 5mg line, or "phrases of speech. While it can be hard to understand what ASD children are saying, their body language is also difficult to understand. Facial expressions, movements, and gestures rarely match what they are saying. Also, their tone of voice fails to reflect their feelings. A high-pitched, sing-song, or flat, robot-like voice is common. Some children with relatively good language skills speak like little adults, failing to pick up on the "kid-speak" that is common in their peers. Without meaningful gestures or the language to ask for things, people with ASD are at a loss to let others know what they need. As a result, they may simply scream or grab what they want. Until they are taught better ways to express their needs, ASD children do whatever they can to get through to others. As people with ASD grow up, they can become increasingly aware of their difficulties in understanding others and in being understood. Although children with ASD usually appear physically normal and have good muscle control, odd repetitive motions may set them off from other children. These behaviors might be extreme and highly apparent or more subtle. Some children and older individuals spend a lot of time repeatedly flapping their arms or walking on their toes. As children, they might spend hours lining up their cars and trains in a certain way, rather than using them for pretend play. If someone accidentally moves one of the toys, the child may be tremendously upset. ASD children need, and demand, absolute consistency in their environment. A slight change in any routine?in mealtimes, dressing, taking a bath, going to school at a certain time and by the same route?can be extremely disturbing. Perhaps order and sameness lend some stability in a world of confusion. Repetitive behavior sometimes takes the form of a persistent, intense preoccupation. For example, the child might be obsessed with learning all about vacuum cleaners, train schedules, or lighthouses. Often there is great interest in numbers, symbols, or science topics. Many ASD children are highly attuned or even painfully sensitive to certain sounds, textures, tastes, and smells. Some children find the feel of clothes touching their skin almost unbearable. Some sounds?a vacuum cleaner, a ringing telephone, a sudden storm, even the sound of waves lapping the shoreline?will cause these children to cover their ears and scream. In ASD, the brain seems unable to balance the senses appropriately. Some ASD children are oblivious to extreme cold or pain. An ASD child may fall and break an arm, yet never cry. Another may bash his head against a wall and not wince, but a light touch may make the child scream with alarm. Many children with ASD have some degree of mental impairment. When tested, some areas of ability may be normal, while others may be especially weak. For example, a child with ASD may do well on the parts of the test that measure visual skills but earn low scores on the language subtests. One in four children with ASD develops seizures, often starting either in early childhood or adolescence. Seizures, caused by abnormal electrical activity in the brain, can produce a temporary loss of consciousness (a "blackout"), a body convulsion, unusual movements, or staring spells. Sometimes a contributing factor is a lack of sleep or a high fever.

They have far more dramatic and intense interpersonal relationships than people with cluster A personality disorders emsam 5 mg low cost. When they fear being abandoned by a caring person purchase 5 mg emsam overnight delivery, they tend to express inappropriate and intense anger. People with a borderline personality tend to see events and relationships as black or white, good or evil, but never neutral. When people with a borderline personality feel abandoned and alone, they may wonder whether they actually exist (that is, they do not feel real). They can become desperately impulsive, engaging in reckless promiscuity, substance abuse, or self-mutilation. At times they are so out of touch with reality that they have brief episodes of psychotic thinking, paranoia, and hallucinations. People with a borderline personality commonly visit primary care doctors. Borderline personality is also the most common personality disorder treated by therapists, because people with the disorder relentlessly seek someone to care for them. However, after repeated crises, vague unfounded complaints, and failures to comply with therapeutic recommendations, caretakers including doctors often become very frustrated with them and view them erroneously as people who prefer complaining to helping themselves. They have a strong desire for affection and acceptance but avoid intimate relationships and social situations for fear of disappointment and criticism. Unlike those with a schizoid personality, they are openly distressed by their isolation and inability to relate comfortably to others. Unlike those with a borderline personality, they do not respond to rejection with anger; instead, they withdraw and appear shy and timid. Avoidant personality is similar to generalized social phobia (see Anxiety Disorders: Social Phobia ). They lack self-confidence and feel intensely insecure about their ability to take care of themselves. They often protest that they cannot make decisions and do not know what to do or how to do it. This behavior is due partly to a reluctance to express their views for fear of offending the people they need and partly to a belief that others are more capable. People with other personality disorders often have traits of a dependent personality, but the dependent traits are usually hidden by the more dominant traits of the other disorder. Sometimes adults with a prolonged illness or physical handicap develop a dependent personality. They are reliable, dependable, orderly, and methodical, but their inflexibility makes them unable to adapt to change. Because they are cautious and weigh all aspects of a problem, they have difficulty making decisions. They take their responsibilities seriously, but because they cannot tolerate mistakes or imperfection, they often have trouble completing tasks. Unlike the mental health disorder called obsessive-compulsive disorder (see Anxiety Disorders: Obsessive-Compulsive Disorder (OCD )), obsessive-compulsive personality does not involve repeated, unwanted obsessions and ritualistic behavior. People with an obsessive-compulsive personality are often high achievers, especially in the sciences and other intellectually demanding fields that require order and attention to detail. However, their responsibilities make them so anxious that they can rarely enjoy their successes. They are uncomfortable with their feelings, with relationships, and with situations in which they lack control or must rely on others or in which events are unpredictable. Passive-Aggressive (Negativistic) Personality: People with a passive-aggressive personality behave in ways that appear inept or passive. However, these behaviors are actually ways to avoid responsibility or to control or punish others. People with a passive-aggressive personality often procrastinate, perform tasks inefficiently, or claim an implausible disability. Frequently, they agree to perform tasks they do not want to perform and then subtly undermine completion of the tasks. Such behavior usually enables them to deny or conceal hostility or disagreements. Cyclothymic Personality: People with cyclothymic personality alternate between high-spirited buoyancy and gloomy pessimism. Mood changes occur regularly and without any identifiable external cause. Many gifted and creative people have this personality type (Depression and Mania: Symptoms and Diagnosis). Depressive Personality: This personality type is characterized by chronic moroseness, worry, and self-consciousness. People have a pessimistic outlook, which impairs their initiative and disheartens others.

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If women value attachment in relationships in a way different from men generic emsam 5 mg without prescription, then the data may suggest a mutually reinforcing process toward strengthening connectedness in lesbian relationships emsam 5 mg otc. In heterosexual and gay male relationships, the value that males place on separateness in relationships may temper the quality of attachment that develops over the years, and therefore results in different forms of psychological intimacy. Psychological intimacy between lesbian partners had a different relational history from that of heterosexual and gay male partners. From the early years to recent years, our data suggest a progressive shift toward psychological intimacy between lesbian partners. Lesbians were as evasiveof face-to-face discussions of conflict as heterosexual and gay male males, during the early years of their relationships. For lesbians, the avoidance appeared to be a consequence of fearing abandonment by their partners if they openly confronted differences. Only as lesbian couples became increasingly disenchanted with their relationships did modification in conflict management styles occur. Usually, one partner took the risk of expressing her unhappiness. That encounter resulted in 85% of lesbians applying for couple therapy. Based on the reports of lesbian respondents about the meaning of therapy to their relationships, being involved in treatment may have supported the development of psychologically intimate communication between partners. Qualitative modes of data collection based on in-depth interviews conducted are an effective tool for studying elusive phenomena, such as psychological intimacy. The richness of data elicited through the method used in this study is quite different from data collected through other means, although there are concerns about validity and reliability, as well as the nature of the sample. Psychological intimacy between lesbian partners had a different relational history from that of heterosexual and gay male partners. From the early years to recent years, our data suggest a progressive shift toward psychological intimacy between lesbian partners. Lesbians were as evasive of face-to-face discussions of conflict as heterosexual and gay male males, during the early years of their relationships. For lesbians, the avoidance appeared to be a consequence of fearing abandonment by their partners if they openly confronted differences. Only as lesbian couples became increasingly disenchanted with their relationships did modification in conflict management styles occur. Usually, one partner took the risk of expressing her unhappiness. That encounter resulted in 85% of lesbians applying for couple therapy. Based on the reports of lesbian respondents about the meaning of therapy to their relationships, being involved in treatment may have supported the development of psychologically intimate communication between partners. It is difficult to assess the validity of the data in the traditional sense of that concept, since we were eliciting the personal perceptions and evaluations of participants about the meaning of psychological intimacy in their relationships at a particular point in time. The candor of participants on highly personal matters, such as the decline in sexual relations because of sexual dysfunctions, suggests that participants were equally candid about other aspects of their relationships, such as psychological intimacy. By interviewing partners separately and asking them to talk about themselves, as well as their observations of their partners in these relationships, we were able to compare responses to determine if there were significant differences over common realities. For example, did both partners assess the nature of conflict in their relationships similarly? Correspondenc e between partners was permitted in the study, which was illustrated in the responses to conflict management styles, when participants were asked to describe their style as well as the style of their partners. For example, partners who described themselves as having an evasive style were viewed by their partners in an equivalent way. In a cross-sectional design in which participants are asked to report on their life today and in the past, traditional measures of reliability are inadequate. While longitudinal designs may be superior in contending with problems of validity and reliability, cross-sectional designs that use interviews to uncover the meaning of behavior have the strength of eliciting the richness in the experiences of human beings. There is a shortfall in recoding the data from multiple categories into dichotomous ones. This step built onto the earlier qualitative analysis by offering a different lens through which to understand the data. To offset the potential reductionistic effects of recoding, we have incorporated a discussion of the qualitative data into the results. The integration of qualitative and quantitative procedures was intended to enhance the theory development objective of the research. The use of an interdisciplinary team throughout the research process enhanced the quality of the study. Issues of bias, misinterpretation, and other matters that could affect the validity and reliability of the data were discussed. One of the principal investigators read all 216 interview transcripts and served as a second blind coder for each interview.

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Friends are great in themselves and they form a vital part of your personal support network order emsam 5mg mastercard. They can throw you a lifeline when you feel like you are drowning in a crisis discount 5 mg emsam with amex. Taking the time to make friends is part of taking care of yourself, and it gives you the opportunity to be a support to others when they are in need (and that can feel pretty good too! Be aware of your good points - find them so that you can encourage others to do the same. You can find out more about developing friendships by reading one of the all-time classics on the subject: " How to Make Friends and Influence People " by Dale Carnegie. If you have persistent difficulties developing and maintaining friendships, then speaking with a counselor can also be helpful. Written by Joyce WoodfordHere are the signs of a healthy relationship and ways to make relationships healthy. Studies show that people with healthy relationships really do have more happiness and less stress. There are basic ways to make relationships healthy, even though each one is different... No one can be everything we might want him or her to be. Healthy relationships mean accepting people as they are and not trying to change them! Sometimes people have emotional messages to share and weave it into their words. Studies show that sharing information especially helps relationships begin. Most of us try to keep people and situations just the way we like them to be. Healthy relationships mean change and growth are allowed! You probably hope those around you like you so you may try to please them. When you have a problem:Negotiate a time to talk about it. Ask, "When is a good time to talk about something that is bothering me? Open sensitive conversations with "I" statements; talk about how you struggle with the problem. Talk with someone who can help you find resolution???like a counselor or therapist, a teacher, a minister or even parents. Be prepared to compromise or to disagree about some things. Studies show that the more we see the best in others, the better healthy relationships get. Healthy relationships are between winners who seek answers to problems together. Studies tell us that loyalty is very important in good relationships, but healthy relationships are NOW, not some hoped-for future development. Studies tell us warmth is highly valued by most people in their relationships. Sometimes it looks like everyone else in the world is confident and connected. Actually, most people feel just like you feel, wondering how to fit in and have good relationships. Healthy relationships can be learned and practiced and keep getting better! Healthy relationships are made of real people, not images! What I call "the masters of marriage " are individuals who are being kind to one another. They may raise difficult issues, but they also soften them in a very considerate way. They communicate respect and love every day in numerous small ways. There are so many more positive exchanges in these relationships, than those that are heading for divorce. These individuals show more affection for each other, and they communicate greater interest in one another, and use more humor. They scan their environment, looking for opportunities to say "thank you" rather than searching for mistakes the other person has made.

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In a 6-week trial (n=367) comparing three fixed doses of ABILIFY (2 mg/day purchase emsam 5mg amex,5 mg/day generic 5 mg emsam fast delivery, or 10 mg/day) to placebo, the 10 mg dose of ABILIFY was superior to placebo in the PANSS total score, the primary outcome measure of the study. The 2 mg and 5 mg doses did not demonstrate superiority to placebo on the primary outcome measure. In a fifth study, a 4-week trial (n=103) comparing ABILIFY in a range of 5 mg/day to 30 mg/day to placebo, ABILIFY was only significantly different compared to placebo in a responder analysis based on the CGI-severity score, a primary outcome for that trial. Thus, the efficacy of 10 mg, 15 mg, 20 mg, and 30 mg daily doses was established in two studies for each dose. Among these doses, there was no evidence that the higher dose groups offered any advantage over the lowest dose group of these studies. An examination of population subgroups did not reveal any clear evidence of differential responsiveness on the basis of age, gender, or race. A longer-term trial enrolled 310 inpatients or outpatients meeting DSM-IV criteria for Schizophrenia who were, by history, symptomatically stable on other antipsychotic medications for periods of 3 months or longer. These patients were discontinued from their antipsychotic medications and randomized to ABILIFY 15 mg/day or placebo for up to 26 weeks of observation for relapse. Relapse during the double-blind phase was defined as CGI-Improvement score of ?-U 5 (minimally worse), scores ?-U 5 (moderately severe) on the hostility or uncooperativeness items of the PANSS, or ?-U 20% increase in the PANSS total score. Patients receiving ABILIFY 15 mg/day experienced a significantly longer time to relapse over the subsequent 26 weeks compared to those receiving placebo. The efficacy of ABILIFY in the treatment of Schizophrenia in pediatric patients (13 to 17 years of age) was evaluated in one 6-week, placebo-controlled trial of outpatients who met DSM-IV criteria for Schizophrenia and had a PANSS score ?-U 70 at baseline. In this trial (n=302) comparing two fixed doses of ABILIFY (10 mg/day or 30 mg/day) to placebo, ABILIFY was titrated starting from 2 mg/day to the target dose in 5 days in the 10 mg/day treatment arm and in 11 days in the 30 mg/day treatment arm. Both doses of ABILIFY were superior to placebo in the PANSS total score, the primary outcome measure of the study. The 30 mg/day dosage was not shown to be more efficacious than the 10 mg/day dose. Although maintenance efficacy in pediatric patients has not been systematically evaluated, maintenance efficacy can be extrapolated from adult data along with comparisons of aripiprazole pharmacokinetic parameters in adult and pediatric patients. The efficacy of ABILIFY in the treatment of acute manic episodes was established in four 3-week, placebo-controlled trials in hospitalized patients who met the DSM-IV criteria for Bipolar I Disorder with manic or mixed episodes. These studies included patients with or without psychotic features and two of the studies also included patients with or without a rapid-cycling course. The primary instrument used for assessing manic symptoms was the Young Mania Rating Scale (Y-MRS), an 11-item clinician-rated scale traditionally used to assess the degree of manic symptomatology (irritability, disruptive/aggressive behavior, sleep, elevated mood, speech, increased activity, sexual interest, language/thought disorder, thought content, appearance, and insight) in a range from 0 (no manic features) to 60 (maximum score). A key secondary instrument included the Clinical Global Impression - Bipolar (CGI-BP) Scale. In the four positive, 3-week, placebo-controlled trials (n=268; n=248; n=480; n=485) which evaluated ABILIFY (aripiprazole) in a range of 15 mg to 30 mg, once daily (with a starting dose of 15 mg/day in two studies and 30 mg/day in two studies), ABILIFY was superior to placebo in the reduction of Y-MRS total score and CGI-BP Severity of Illness score (mania). In the two studies with a starting dose of 15 mg/day, 48% and 44% of patients were on 15 mg/day at endpoint. In the two studies with a starting dose of 30 mg/day,86% and 85% of patients were on 30 mg/day at endpoint. A trial was conducted in patients meeting DSM-IV criteria for Bipolar I Disorder with a recent manic or mixed episode who had been stabilized on open-label ABILIFY and who had maintained a clinical response for at least 6 weeks. The first phase of this trial was an open-label stabilization period in which inpatients and outpatients were clinically stabilized and then maintained on open-label ABILIFY (15 mg/day or 30 mg/day, with a starting dose of 30 mg/day) for at least 6 consecutive weeks. One hundred sixty-one outpatients were then randomized in a double-blind fashion, to either the same dose of ABILIFY they were on at the end of the stabilization and maintenance period or placebo and were then monitored for manic or depressive relapse. During the randomization phase, ABILIFY was superior to placebo on time to the number of combined affective relapses (manic plus depressive), the primary outcome measure for this study. The majority of these relapses were due to manic rather than depressive symptoms. There is insufficient data to know whether ABILIFY is effective in delaying the time to occurrence of depression in patients with Bipolar I Disorder. An examination of population subgroups did not reveal any clear evidence of differential responsiveness on the basis of age and gender; however, there were insufficient numbers of patients in each of the ethnic groups to adequately assess inter-group differences. The efficacy of ABILIFY in the treatment of Bipolar I Disorder in pediatric patients (10 to 17 years of age) was evaluated in one four-week placebo-controlled trial (n=296) of outpatients who met DSM-IV criteria for Bipolar I Disorder manic or mixed episodes with or without psychotic features and had a Y-MRS score ?-U 20 at baseline. This double-blind, placebo-controlled trial compared two fixed doses of ABILIFY (10 mg/day or 30 mg/day) to placebo. The ABILIFY dose was started at 2 mg/day, which was titrated to 5 mg/day after 2 days, and to the target dose in 5 days in the 10 mg/day treatment arm and in 13 days in the 30 mg/day treatment arm. Both doses of ABILIFY were superior to placebo in change from baseline to week 4 on the Y-MRS total score. Although maintenance efficacy in pediatric patients has not been systematically evaluated, maintenance efficacy can be extrapolated from adult data along with comparisons of aripiprazole pharmacokinetic parameters in adult and pediatric patients. The efficacy of adjunctive ABILIFY with concomitant lithium or valproate in the treatment of manic or mixed episodes was established in a 6-week, placebo-controlled study (n=384) with a 2-week lead-in mood stabilizer monotherapy phase in adult patients who met DSM-IV criteria for Bipolar I Disorder. This study included patients with manic or mixed episodes and with or without psychotic features. At the end of 2 weeks, patients demonstrating inadequate response (Y-MRS total score ?-U 16 and ?-T 25% improvement on the Y-MRS total score) to lithium or valproate were randomized to receive either aripiprazole (15 mg/day or an increase to 30 mg/day as early as day 7) or placebo as adjunctive therapy with open-label lithium or valproate.

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9 of 10 - Review by T. Karmok
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